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Long-read sequencing reveals pre-meiotic gene conversion in sperm

Nature, Published online: 26 August 2026; doi:10.1038/s41586-026-10901-0 Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meiosis, distinct from PRDM9-driven recombination and associated with fragile sites.