Cell-type-specific eQTLs underlie the genetic architecture of complex traits
Nature, Published online: 26 August 2026; doi:10.1038/s41586-026-10577-6 Single-cell RNA-sequencing shows that cell-type-specific expression quantitative trait loci drive much of complex trait heritability, highlighting cell-type-specific gene regulation as key to linking genetic variants with traits.
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Cell-type-specific eQTLs underlie the genetic architecture of complex traits
Nature, Published online: 26 August 2026; doi:10.1038/s41586-026-10577-6 Single-cell RNA-sequencing shows that cell-type-specific expression quantitative trait loci drive much of complex trait heritability, highlighting cell-type-specific gene regulation as key to linking genetic variants with traits.