ادغام و بازآرایی ژنومی هدفمند با استفاده از مونتاژ اولیه

Targeted genomic integration and rearrangement using prime assembly

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11024-2 Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding, transgene insertion and megabase-scale rearrangements.