یک محور سرپین – میلوئید در ناهمگونی سرطان پانکراس و فرار ایمنی

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8 SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.