فکر کردن در خارج از محل اتصال: مولکول دارو یک میخ مربعی را متناسب با سوراخ گرد می کند

Thinking outside the binding site: Drug molecule makes a square peg fit a round hole

A square peg doesn't fit a round hole. But what if the peg could change the shape of the hole? A newly developed drug molecule can do something surprisingly similar when binding to its target protein, according to a University at Buffalo-led study published Tuesday (Sept. 15) in Angewandte Chemie International Edition.